Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 3/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 7/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2239319 | 0.82 | CHUK (0.51) | CHUKIKBKBROCK1SIRT1CCNK | |
| SCHEMBL13012932 | 0.79 | ECE2 (0.43) | CCNKCDK12KDM4EALDH1A1 | |
| SCHEMBL1841180 | 0.76 | CHUK (0.59) | CHUKIKBKBROCK1CCNKCDK12 | |
| SCHEMBL29588892 | 0.73 | RIPK1 (0.52) | SIRT1 | |
| SCHEMBL15646003 | 0.70 | CHUK (0.41) | CHUKIKBKBROCK1CCNKCDK12 | |
| SCHEMBL13505067 | 0.70 | IKBKB (0.85) | CHUKIKBKBROCK1CCNKCDK12 | |
| SCHEMBL3416746 | 0.69 | PRKCI (0.40) | CHUKIKBKBROCK1CCNKCDK12 | |
| SCHEMBL3417659 | 0.69 | IKBKB (1.00) | CHUKIKBKBROCK1CCNKCDK12 | |
| SCHEMBL13505099 | 0.68 | PRKCI (0.39) | CHUKIKBKBROCK1CCNKCDK12 | |
| SCHEMBL3417614 | 0.66 | PRKCI (0.37) | CHUKIKBKBROCK1CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008034860-A1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-03-27 | — | — | WO | disclosed |