Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 10/20 | 0.59 |
| ▸ | TYK2 | P29597 | 10/20 | 0.59 |
| ▸ | JAK2 | O60674 | 9/20 | 0.59 |
| ▸ | JAK3 | P52333 | 8/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2573565 | 0.92 | JAK1 (0.58) | JAK1TYK2JAK2JAK3PRMT5 | |
| SCHEMBL2575954 | 0.84 | JAK2 (0.59) | JAK1TYK2JAK2JAK3MAPT | |
| SCHEMBL2571831 | 0.83 | JAK1 (0.58) | JAK1TYK2JAK2JAK3MAPT | |
| SCHEMBL2571744 | 0.83 | TYK2 (0.70) | JAK1TYK2JAK2JAK3MAPT | |
| SCHEMBL2569579 | 0.82 | JAK1 (0.71) | JAK1TYK2JAK2JAK3MAPT | |
| SCHEMBL2574165 | 0.80 | JAK1 (0.80) | JAK1TYK2JAK2JAK3MAPT | |
| SCHEMBL2575207 | 0.79 | JAK1 (0.78) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL2577250 | 0.79 | JAK1 (0.72) | JAK1TYK2JAK2JAK3FLT3 | |
| SCHEMBL14256422 | 0.78 | CA2 (0.56) | JAK1TYK2JAK2JAK3GAA | |
| SCHEMBL14280403 | 0.73 | JAK2 (0.47) | JAK1TYK2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008031594-A1 | BENZOXAZOLES AND OXAZOLOPYRIDINES BEING USEFUL AS JANUS KINASES INHIBITORS | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |