Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.54 |
| ▸ | CACNA1H | O95180 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280465 | 0.99 | TRPV1 (0.55) | TRPV1CACNA1HALDH1A1POLB | |
| SCHEMBL14280511 | 0.89 | TRPV1 (0.52) | TRPV1CACNA1HALDH1A1POLBPAX8 | |
| SCHEMBL8210399 | 0.88 | TRPV1 (0.59) | TRPV1CACNA1HALDH1A1POLBPAX8 | |
| SCHEMBL8210157 | 0.81 | TRPV1 (0.79) | TRPV1CACNA1HPOLB | |
| SCHEMBL8202713 | 0.80 | TRPV1 (0.81) | TRPV1CACNA1HPOLB | |
| SCHEMBL14265958 | 0.79 | TRPV1 (0.42) | TRPV1CACNA1HALDH1A1POLB | |
| SCHEMBL14265980 | 0.78 | TRPV1 (0.43) | TRPV1CACNA1H | |
| SCHEMBL8201879 | 0.77 | CACNA1H (0.63) | TRPV1CACNA1H | |
| SCHEMBL8209936 | 0.76 | HSD11B1 (0.50) | TRPV1CACNA1H | |
| SCHEMBL8209202 | 0.76 | CACNA1H (0.54) | TRPV1CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033431-A1 | SPIROCYCLIC AZETIDINONE DERIVATIVES FOR THE TREATMENT OF DISORDERS OF LIPID METABOLISM, PAIN, DIABETES AND OTHER DISORDERS | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |