Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 9/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404205 | 0.79 | NPSR1 (0.35) | CCR1CCR5CCR8ERN1NAPRT | |
| SCHEMBL15729618 | 0.78 | CA12 (0.42) | KDM4EALDH1A1NPSR1 | |
| SCHEMBL16414338 | 0.77 | NAPRT (0.38) | NAPRTKDM4EASPHKDM8ALDH1A1 | |
| SCHEMBL29951769 | 0.77 | ERN1 (0.48) | CCR1CCR5CCR8ERN1KDM4E | |
| SCHEMBL28700162 | 0.76 | NAPRT (0.37) | CCR1CCR5CCR8NAPRTKDM4E | |
| SCHEMBL2674661 | 0.74 | NAPRT (0.36) | NAPRTKDM4EASPHKDM8ALDH1A1 | |
| SCHEMBL29955484 | 0.73 | CCR1 (0.45) | CCR1CCR5CCR8ERN1NAPRT | |
| Bromide SCHEMBL4181790 | 0.73 | KDM4E (0.38) | NAPRTKDM4EASPHKDM8ALDH1A1 | |
| SCHEMBL29955416 | 0.72 | CCR1 (0.48) | CCR1CCR5CCR8ERN1NAPRT | |
| SCHEMBL28114355 | 0.72 | CCR1 (0.48) | CCR1CCR5CCR8ERN1NAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320992-B2 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use | AMGEN INC. (US) | 2008-01-22 | — | — | US | disclosed |