Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | BUB1 | O43683 | 1/20 | 0.44 |
| ▸ | GUCY1A1 | Q02108 | 5/20 | 0.43 |
| ▸ | GUCY1B1 | Q02153 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14282088 | 0.91 | ADORA3 (0.55) | PDE5AADORA3KCNH2BUB1GUCY1A1 | |
| SCHEMBL14282086 | 0.90 | ADORA3 (0.54) | PDE5AADORA3KCNH2BUB1GUCY1A1 | |
| SCHEMBL14282089 | 0.89 | ADORA3 (0.57) | PDE5AADORA3KCNH2BUB1GUCY1A1 | |
| SCHEMBL14282081 | 0.88 | ADORA3 (0.59) | PDE5AADORA3KCNH2BUB1GUCY1A1 | |
| SCHEMBL4931257 | 0.87 | ADORA3 (0.56) | PDE5AADORA3KCNH2BUB1GUCY1A1 | |
| SCHEMBL14282080 | 0.85 | ADORA3 (0.60) | PDE5AADORA3KCNH2BUB1GUCY1A1 | |
| SCHEMBL14282090 | 0.84 | ADORA3 (0.56) | PDE5AADORA3KCNH2BUB1GUCY1A1 | |
| SCHEMBL14282083 | 0.83 | ADORA3 (0.57) | PDE5AADORA3KCNH2BUB1GUCY1A1 | |
| SCHEMBL14282082 | 0.83 | ADORA3 (0.55) | PDE5AADORA3KCNH2BUB1GUCY1A1 | |
| SCHEMBL4939648 | 0.81 | ADORA3 (0.64) | PDE5AADORA3KCNH2BUB1GUCY1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317016-B2 | Methods of treating medical conditions using sulfonate-substituted pyrazolopyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2008-01-08 | — | — | US | disclosed |
| US-7317016-B2 | Methods of treating medical conditions using sulfonate-substituted pyrazolopyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2008-01-08 | — | — | US | disclosed |