Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3621519 | 0.90 | MEN1 (0.48) | MEN1KMT2AATMPOLBPKM | |
| SCHEMBL4007588 | 0.89 | MEN1 (0.48) | MEN1KMT2AATMPOLBPKM | |
| SCHEMBL13408180 | 0.88 | IKBKB (0.44) | MEN1KMT2AATMPOLBPKM | |
| SCHEMBL13442268 | 0.88 | MEN1 (0.43) | MEN1KMT2AATMPOLBPKM | |
| Trifluoroacetic Acid SCHEMBL3624358 | 0.82 | KMT2A (0.42) | MEN1KMT2AATMPOLBPKM | |
| SCHEMBL3621225 | 0.81 | IKBKB (0.47) | JAK2ALDH1A1MAPK10 | |
| SCHEMBL14283347 | 0.81 | MAPK10 (0.60) | JAK2MAPK10 | |
| SCHEMBL13442607 | 0.79 | MAPK10 (0.45) | MAPK10 | |
| SCHEMBL13408178 | 0.79 | IKBKB (0.46) | CDK2MAPK10 | |
| SCHEMBL14283339 | 0.77 | RIPK1 (0.46) | ATMPOLBPKMHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008034600-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | NOVARTIS AG (CH) | 2008-03-27 | — | — | WO | disclosed |