Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 10/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.34 |
| ▸ | HTR2C | P28335 | 5/20 | 0.33 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | HTR2B | P41595 | 4/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4955856 | 0.83 | HTR2C (0.40) | CCNE1CDK2PDE4APDE4BPDE4C | |
| SCHEMBL4955065 | 0.81 | HTR2C (0.40) | CCNE1CDK2PDE4APDE4BPDE4C | |
| SCHEMBL4955385 | 0.80 | HTR2C (0.41) | CCNE1CDK2PDE4APDE4BPDE4C | |
| SCHEMBL4958235 | 0.78 | CYP1A2 (0.39) | HTR2CHTR2AHTR2B | |
| SCHEMBL4958797 | 0.73 | PDE10A (0.42) | CDK2HTR2CHTR2AHTR2BCCNT1 | |
| SCHEMBL4955710 | 0.70 | HRH3 (0.51) | — | |
| SCHEMBL4953120 | 0.67 | HTR2C (0.36) | PDE4APDE4BPDE4CPDE4DHTR2C | |
| SCHEMBL4953186 | 0.64 | HTR2C (0.46) | HTR2CHTR2AHTR2B | |
| SCHEMBL4954460 | 0.64 | WDR5 (0.48) | — | |
| SCHEMBL4958926 | 0.61 | HTR2C (0.46) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319103-B2 | Non-imidazole tertiary amines as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | ATHERSYS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319103-B2 | Non-imidazole tertiary amines as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | ATHERSYS, INC. (US) | 2008-01-15 | — | — | US | disclosed |