Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.69 |
| ▸ | DRD1 | P21728 | 3/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.69 |
| ▸ | DRD3 | P35462 | 3/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.69 |
| ▸ | HTR1A | P08908 | 2/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL10436003 | 0.90 | MAPK1 (0.59) | CHRM2ADRA2ACHRM1DRD1SLC6A2 | |
| SCHEMBL14282902 | 0.88 | DRD3 (0.69) | CHRM2ADRA2ACHRM1DRD1SLC6A2 | |
| SCHEMBL14274108 | 0.84 | CYP2D6 (0.49) | CHRM2ADRA2ACHRM1DRD1SLC6A2 | |
| SCHEMBL9682033 | 0.83 | DRD3 (0.54) | CHRM2ADRA2ACHRM1DRD1SLC6A2 | |
| Hydrochloric Acid SCHEMBL1151739 | 0.82 | MEN1 (0.58) | CHRM2ADRA2ACHRM1DRD1SLC6A2 | |
| Diphenylpyraline SCHEMBL119077 | 0.81 | DRD3 (1.00) | CHRM2ADRA2ACHRM1DRD1SLC6A2 | |
| SCHEMBL6621510 | 0.81 | CHRM2 (0.65) | CHRM2ADRA2ACHRM1DRD1SLC6A2 | |
| SCHEMBL7976350 | 0.81 | CHRM2 (0.65) | CHRM2ADRA2ACHRM1DRD1SLC6A2 | |
| Hydrochloric Acid SCHEMBL11397869 | 0.80 | MAPK1 (0.66) | CHRM2ADRA2ACHRM1DRD1SLC6A2 | |
| SCHEMBL14282953 | 0.80 | BCHE (0.59) | CHRM2ADRA2ACHRM1DRD1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |