Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylpyraline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 3/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | DRD2 | P14416 | 2/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylpyraline SCHEMBL212198 | 0.98 | MAPK1 (1.00) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| Diphenylpyraline SCHEMBL4543024 | 0.97 | DRD3 (0.93) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| SCHEMBL9673190 | 0.91 | CHRM1 (0.82) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL9357212 | 0.89 | MAPK1 (0.83) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL9357058 | 0.87 | MAPK1 (0.78) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL9353118 | 0.85 | MAPK1 (0.74) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| SCHEMBL18469978 | 0.84 | CHRM1 (0.73) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| SCHEMBL2056216 | 0.83 | DRD3 (0.71) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| Maleic Acid SCHEMBL9353012 | 0.83 | SLC6A3 (0.68) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| SCHEMBL14282902 | 0.82 | DRD3 (0.69) | DRD3SLC6A2CYP2D6CHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5059 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| WO-2026042047-A1 | COMPOSITIONS AND ARTICLES COMPRISING REVERSIBLE COMPLEXES OF CROSSLINKED CARRAGEENAN | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2026-02-26 | — | — | WO | claimed |
| EP-4247331-B1 | ORODISPERSIBLE POWDER COMPOSITION COMPRISING AN ANTIHISTAMINE COMPOUND | BIOPHARMA SYNERGIES S L (ES) | 2025-10-08 | — | — | EP | claimed |
| WO-2025136243-A1 | MECHANOCHEMICAL SYNTHESIS OF HISTAMINE H1-RECEPTOR ANTAGONISTS | IHSAN DOGRAMACI BILKENT UNIVERSITESI (TR) | 2025-06-26 | — | — | WO | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| CN-119482562-A | Three-phase unbalanced load adjusting method based on improved mayday algorithm | 江苏方天电力技术有限公司 | 2025-02-18 | — | — | CN | claimed |
| US-20250032643-A1 | SYNTHETIC RECEPTORS | UCL BUSINESS LTD (GB) | 2025-01-30 | — | — | US | claimed |
| CN-112368300-B | SPNS2 neutralizing antibodies | 帝人制药株式会社 | 2024-10-01 | — | — | CN | claimed |
| EP-4337683-A1 | SYNTHETIC RECEPTORS | UCL Business Ltd (GB) | 2024-03-20 | — | — | EP | claimed |
| CN-117472142-A | Photovoltaic multimodal maximum power tracking method based on improved dayfish algorithm | 国网河南省电力公司驻马店供电公司 | 2024-01-30 | — | — | CN | claimed |
| EP-0714292-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1996-06-05 | — | — | EP | claimed |
| WO-1995000131-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE, INCORPORATED (US) | 1995-01-05 | — | — | WO | claimed |
| EP-0599943-A1 | LEUKOTRIENE RECEPTOR ANTAGONIST-ANTIHISTAMINE COMPLEX | ALLERGAN, INC. (US) | 1994-06-08 | — | — | EP | claimed |
| WO-1993003723-A1 | LEUKOTRIENE RECEPTOR ANTAGONIST-ANTIHISTAMINE COMPLEX | ALLERGAN, INC. (US) | 1993-03-04 | — | — | WO | claimed |
| US-5183665-A | Using antihistamine | NITTO DENKO CORPORATION (JP) | 1993-02-02 | — | — | US | claimed |
| US-4952402-A | EDIBLE TASTE-MASKED DRUGS; MICROMATRIX ACTIVE MATERIAL COATED WITH NONTOXIC POLYMER; LIQUIDS; TABLETS | ELAN CORPORATION, P.L.C. (IE) | 1990-08-28 | — | — | US | claimed |
| US-4749700-A | NASAL ADMINISTRATION LOWER DOSAGE | NASTECH PHARMACEUTICAL CO, INC. (US) | 1988-06-07 | — | — | US | claimed |
| US-4104382-A | (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-01 | — | — | US | claimed |
| US-4000302-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-12-28 | — | — | US | claimed |
| US-3978220-A | (4-(DIPHENYLMETHOXY-1-METHYLPIPERIDINIUM)-4-(1-HYDROXY-2-(1-METHYL-3 -PHENYLPROPYL-AMINO)-PROPYL)PHENOLATE ANTIINFLAMMATORY | TROPONWERKE DINKLAGE & COMPANY (DT) | 1976-08-31 | — | — | US | claimed |