SCHEMBL14285229

SCHEMBL14285229

CCC(=O)Nc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1

nearest known ligand 0.73

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
LHCGR P22888 15/20 0.73
FSHR P23945 4/20 0.71
TSHR P16473 2/20 0.71
BRAF P15056 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5028843 0.92 LHCGR (0.72) LHCGRFSHRTSHRBRAF
SCHEMBL4425858 0.89 LHCGR (0.71) LHCGRFSHRTSHRBRAF
SCHEMBL4425902 0.89 LHCGR (0.78) LHCGRFSHRTSHRBRAF
SCHEMBL6222004 0.89 LHCGR (0.68) LHCGRFSHRTSHRBRAF
SCHEMBL6222712 0.88 LHCGR (0.69) LHCGRFSHRTSHR
SCHEMBL5028832 0.88 LHCGR (0.67) LHCGRFSHRTSHR
SCHEMBL5028842 0.88 LHCGR (0.67) LHCGRFSHRTSHR
SCHEMBL30673520 0.88 LHCGR (0.67) LHCGRFSHRTSHR
SCHEMBL6221420 0.88 LHCGR (0.69) LHCGRFSHRTSHR
SCHEMBL30673524 0.88 LHCGR (0.67) LHCGRFSHRTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7317006-B2 Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity N.V. ORGANON (NL) 2008-01-08 US disclosed