Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909305 | 0.87 | ALDH1A1 (0.48) | ALDH1A1MAPTBACE1KDM4EMEN1 | |
| SCHEMBL14308658 | 0.85 | ALDH1A1 (0.51) | RXFP1ALDH1A1THRBTDP1MAPT | |
| SCHEMBL4911250 | 0.81 | RXFP1 (0.53) | RXFP1ALDH1A1THRBTDP1MAPT | |
| SCHEMBL4427518 | 0.78 | MYC (0.46) | RXFP1ALDH1A1THRBMAPTBACE1 | |
| SCHEMBL4419269 | 0.77 | GRK6 (0.41) | RXFP1ALDH1A1THRBMAPTBACE1 | |
| SCHEMBL4419984 | 0.76 | MYC (0.51) | RXFP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4422399 | 0.76 | CYP1A2 (0.56) | RXFP1ALDH1A1THRBMAPTMEN1 | |
| SCHEMBL27524700 | 0.76 | MAPT (0.37) | ALDH1A1THRBMAPTBACE1KDM4E | |
| SCHEMBL4419266 | 0.75 | BACE1 (0.41) | RXFP1ALDH1A1MAPTBACE1KDM4E | |
| SCHEMBL4419260 | 0.75 | BACE1 (0.41) | RXFP1ALDH1A1MAPTBACE1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317006-B2 | Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity | N.V. ORGANON (NL) | 2008-01-08 | — | — | US | disclosed |