Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13844350 | 0.80 | AR (0.53) | TP53 | |
| SCHEMBL13492110 | 0.78 | CA1 (0.47) | SLC6A2SLC6A4SLC6A3KCNH2TP53 | |
| SCHEMBL8358603 | 0.77 | TP53 (0.53) | SLC6A2SLC6A4SLC6A3KCNH2TP53 | |
| SCHEMBL18929676 | 0.75 | CA1 (0.50) | SLC6A2SLC6A4SLC6A3KCNH2TP53 | |
| SCHEMBL14687798 | 0.74 | POLB (0.53) | SLC6A2SLC6A4SLC6A3KCNH2TP53 | |
| SCHEMBL3552574 | 0.74 | POLB (0.52) | TP53POLB | |
| SCHEMBL10053513 | 0.73 | CA1 (0.54) | SLC6A2SLC6A4SLC6A3KCNH2TP53 | |
| SCHEMBL14286006 | 0.72 | AR (0.54) | — | |
| SCHEMBL14138987 | 0.71 | TP53 (0.46) | SLC6A2SLC6A4SLC6A3KCNH2TP53 | |
| SCHEMBL28131534 | 0.71 | HTR6 (0.54) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008030902-A1 | ALKYLENE BRIDGED SULTAM COMPOUNDS USEFUL AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-03-13 | — | — | WO | disclosed |