Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14286135 | 0.88 | ROCK2 (0.41) | MAPK1MAPK10GSK3BKCNH2MEN1 | |
| SCHEMBL14278772 | 0.85 | MAPK1 (0.49) | MAPK1MAPK10GSK3BKCNH2L3MBTL1 | |
| SCHEMBL14600763 | 0.84 | GSK3B (0.44) | GSK3BKCNH2HPGDALDH1A1CYP1A2 | |
| SCHEMBL14286150 | 0.84 | GSK3B (0.51) | MAPK1MAPK10GSK3BKCNH2L3MBTL1 | |
| SCHEMBL14278771 | 0.81 | MAPK1 (0.49) | MAPK1MAPK10GSK3BKCNH2L3MBTL1 | |
| SCHEMBL14286165 | 0.80 | GSK3B (0.51) | MAPK1MAPK10GSK3BKCNH2L3MBTL1 | |
| SCHEMBL14286163 | 0.80 | GSK3B (0.49) | MAPK1MAPK10GSK3BKCNH2L3MBTL1 | |
| SCHEMBL14286127 | 0.78 | GSK3B (0.56) | MAPK1MAPK10GSK3BKCNH2L3MBTL1 | |
| SCHEMBL14278769 | 0.78 | GSK3B (0.55) | MAPK1MAPK10GSK3BKCNH2L3MBTL1 | |
| SCHEMBL5033986 | 0.77 | NOTUM (0.36) | MAPK1MAPK10GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314885-B2 | Pyrrole compounds useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-01-01 | — | — | US | disclosed |
| US-7314885-B2 | Pyrrole compounds useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-01-01 | — | — | US | disclosed |