Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637999 | 0.88 | ABHD6 (0.65) | ABHD6ESR2NR1H2MAPK1MTNR1A | |
| SCHEMBL15062790 | 0.88 | ESR2 (0.51) | ABHD6ESR2NR1H2MAPK1MAPT | |
| SCHEMBL21659367 | 0.86 | ESR2 (0.47) | ABHD6ESR2NR1H2MAPK1MAPT | |
| SCHEMBL19608875 | 0.85 | ESR2 (0.56) | ABHD6ESR2NR1H2MAPK1MAPT | |
| SCHEMBL16518212 | 0.85 | ABHD6 (0.46) | ABHD6ESR2NR1H2MAPK1PTGDR2 | |
| SCHEMBL16268884 | 0.84 | PTGDR2 (0.52) | ABHD6ESR2NR1H2MAPK1DDB1 | |
| SCHEMBL30199091 | 0.84 | ESR2 (0.59) | ABHD6ESR2NR1H2MAPK1MAPT | |
| SCHEMBL3693657 | 0.84 | ESR2 (0.59) | ABHD6ESR2NR1H2MAPK1MAPT | |
| SCHEMBL19178532 | 0.83 | ESR2 (0.47) | ABHD6ESR2NR1H2MAPK1DDB1 | |
| SCHEMBL4519564 | 0.83 | NR1H2 (0.60) | ABHD6ESR2NR1H2MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | disclosed |
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | disclosed |