Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | SCN1A | P35498 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | RAD52 | P43351 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097548 | 0.95 | HRH3 (0.71) | HRH3KCNH2MAPK1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL5100664 | 0.94 | HRH3 (0.70) | HRH3KCNH2MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL14287674 | 0.92 | HRH3 (0.68) | HRH3ACHERAD52 | |
| SCHEMBL3181015 | 0.88 | CYP2C19 (0.74) | HRH3CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL14287678 | 0.87 | HRH3 (0.68) | HRH3ACHERAD52 | |
| SCHEMBL3182761 | 0.87 | CYP2C19 (0.68) | HRH3CYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL14287660 | 0.87 | HRH3 (0.68) | HRH3ACHERAD52 | |
| SCHEMBL14287710 | 0.86 | HRH3 (0.70) | HRH3ACHERAD52 | |
| SCHEMBL3175514 | 0.86 | CYP2C19 (0.70) | HRH3CYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL3173535 | 0.86 | CYP2C19 (0.70) | HRH3CYP3A4CYP2D6CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | disclosed |
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | disclosed |