Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | AIP | O00170 | 1/20 | 0.34 |
| ▸ | SGTA | O43765 | 1/20 | 0.34 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.34 |
| ▸ | STIP1 | P31948 | 1/20 | 0.34 |
| ▸ | PPP5C | P53041 | 1/20 | 0.34 |
| ▸ | DNAJC7 | Q99615 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14293180 | 0.94 | MAPT (0.44) | MAPTTP53KDM4EALDH1A1RAB9A | |
| SCHEMBL1209615 | 0.91 | ALDH1A1 (0.44) | MAPTTP53ALDH1A1RAB9APOLB | |
| SCHEMBL14292975 | 0.89 | MAPT (0.41) | MAPTTP53KDM4EALDH1A1RAB9A | |
| SCHEMBL12895488 | 0.86 | ALDH1A1 (0.44) | MAPTTP53KDM4EALDH1A1RAB9A | |
| SCHEMBL12895457 | 0.86 | MAPT (0.39) | MAPTTP53ALDH1A1ALPLALPI | |
| SCHEMBL14293205 | 0.85 | MAPT (0.38) | MAPTTP53ALDH1A1ALPLALPI | |
| SCHEMBL1209347 | 0.85 | ALDH1A1 (0.44) | MAPTTP53KDM4EALDH1A1RAB9A | |
| SCHEMBL14293195 | 0.83 | MAPT (0.37) | MAPTTP53ALDH1A1ALPLALPI | |
| SCHEMBL14292974 | 0.83 | TP53 (0.45) | MAPTTP53KDM4EALDH1A1RAB9A | |
| SCHEMBL14293342 | 0.83 | MAPT (0.39) | MAPTTP53KDM4EALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020045-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2008-02-21 | — | — | WO | disclosed |