Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.43 |
| ▸ | CLK2 | P49760 | 4/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185553 | 0.79 | MAPT (0.56) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL868188 | 0.78 | MAPT (0.60) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL438061 | 0.76 | MAPT (0.53) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL899715 | 0.76 | MAPT (0.53) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL14293291 | 0.76 | MAP4K4 (0.53) | CSNK2A1MAP4K4CLK2MAP4K2DYRK1A | |
| SCHEMBL30323242 | 0.76 | MAPT (0.53) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL2185527 | 0.76 | SMN1; SMN2 (0.58) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL14968875 | 0.72 | MAPT (0.49) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL2185814 | 0.72 | HTT (0.49) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL3795260 | 0.72 | MAPT (0.49) | MAPTSMN1; SMN2HTTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008018881-A1 | 6,6-BICYCLIC RING SUBSTITUTED SULFUR CONTAINING HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |