Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 11/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 11/20 | 0.53 |
| ▸ | KDR | P35968 | 11/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.53 |
| ▸ | LCK | P06239 | 9/20 | 0.53 |
| ▸ | CLK2 | P49760 | 8/20 | 0.53 |
| ▸ | MET | P08581 | 8/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 8/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.53 |
| ▸ | RET | P07949 | 6/20 | 0.53 |
| ▸ | GSK3B | P49841 | 6/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.53 |
| ▸ | CSF1R | P07333 | 6/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.53 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.53 |
| ▸ | TAOK1 | Q7L7X3 | 5/20 | 0.53 |
| ▸ | ABL1 | P00519 | 5/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869609 | 0.78 | KDR (0.54) | MAP4K4MAP4K2KDRCLK4LCK | |
| SCHEMBL3868631 | 0.76 | MAP4K4 (0.57) | MAP4K4MAP4K2KDRCLK4LCK | |
| SCHEMBL14293148 | 0.72 | — | — | |
| SCHEMBL18590960 | 0.72 | MAP4K4 (0.49) | MAP4K4MAP4K2KDRCLK4LCK | |
| SCHEMBL6926673 | 0.72 | KDR (0.49) | MAP4K4MAP4K2KDRCLK4LCK | |
| SCHEMBL4488134 | 0.70 | KDR (0.66) | MAP4K4MAP4K2KDRCLK4LCK | |
| SCHEMBL14013968 | 0.69 | FGFR1 (1.00) | MAP4K4MAP4K2KDRCLK4LCK | |
| SCHEMBL4482587 | 0.68 | KDR (0.62) | MAP4K4MAP4K2KDRCLK4LCK | |
| SCHEMBL14414209 | 0.67 | MAP4K4 (0.63) | MAP4K4MAP4K2KDRCLK4LCK | |
| SCHEMBL900963 | 0.66 | KDR (0.44) | MAP4K4MAP4K2KDRCLK4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008018881-A1 | 6,6-BICYCLIC RING SUBSTITUTED SULFUR CONTAINING HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |