Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | GFER | P55789 | 2/20 | 0.33 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | PDE6A | P16499 | 1/20 | 0.33 |
| ▸ | PDE6B | P35913 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916582 | 0.75 | HRH4 (0.38) | NPC1RAB9AGAAKDM4EHPGD | |
| SCHEMBL6125859 | 0.73 | DYRK1A (0.37) | GAAHSD17B10ALDH1A1MAPTGRM5 | |
| SCHEMBL31221748 | 0.73 | MET (0.46) | SMN1; SMN2HSD17B10HTTALDH1A1MAPT | |
| SCHEMBL1104630 | 0.73 | MET (0.46) | SMN1; SMN2HSD17B10HTTALDH1A1MAPT | |
| SCHEMBL13750010 | 0.73 | HDAC1 (0.33) | NPC1RAB9AGAAKDM4EHPGD | |
| SCHEMBL12524654 | 0.72 | GRM5 (0.46) | NPC1RAB9AGAAKDM4EHPGD | |
| SCHEMBL8738054 | 0.70 | NPC1 (0.54) | NPC1RAB9AGAAKDM4EHPGD | |
| SCHEMBL764284 | 0.70 | NPC1 (0.66) | NPC1RAB9AGAAKDM4EHPGD | |
| SCHEMBL19836262 | 0.70 | HRH3 (0.38) | NPC1RAB9AGAAKDM4EHPGD | |
| SCHEMBL22152275 | 0.69 | PIK3CB (0.39) | NPC1RAB9AGAAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332476-B2 | Pyridyl substituted ketolide antibiotics | NOVARTIS AG (CH) | 2008-02-19 | — | — | US | disclosed |