Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.70 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993064 | 0.84 | FAAH (0.76) | FAAHGRM5SMN1; SMN2LMNAGAA | |
| SCHEMBL1429881 | 0.83 | FAAH (0.72) | FAAHGRM5SMN1; SMN2LMNAGAA | |
| SCHEMBL8006312 | 0.82 | FAAH (1.00) | FAAHGRM5SMN1; SMN2LMNAGAA | |
| SCHEMBL1302433 | 0.81 | FAAH (0.72) | FAAHGRM5SMN1; SMN2LMNAGAA | |
| SCHEMBL8008516 | 0.81 | FAAH (0.71) | FAAHGRM5SMN1; SMN2LMNAGAA | |
| SCHEMBL1302607 | 0.80 | FAAH (0.70) | FAAHGRM5SMN1; SMN2LMNAGAA | |
| SCHEMBL1430227 | 0.80 | FAAH (0.64) | FAAHGRM5SMN1; SMN2LMNAGAA | |
| SCHEMBL1304088 | 0.80 | FAAH (0.69) | FAAHGRM5SMN1; SMN2LMNAGAA | |
| SCHEMBL1303678 | 0.80 | FAAH (0.69) | FAAHGRM5SMN1; SMN2LMNAGAA | |
| SCHEMBL1303133 | 0.80 | FAAH (0.69) | FAAHGRM5SMN1; SMN2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300438-A1 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | Merck Sharp & Dohme Corp. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009152025-A1 | IMIDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |