Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 7/20 | 0.54 |
| ▸ | EYA3 | Q99504 | 3/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11637488 | 0.82 | CYP2C19 (0.48) | CYP2C19EYA3SLC22A12CYP2C9KMT2A | |
| SCHEMBL1253874 | 0.81 | CYP2D6 (0.39) | CYP2C19EYA3CYP2C9HRH1CYP2D6 | |
| SCHEMBL11640926 | 0.80 | CYP2C19 (0.50) | CYP2C19EYA3SLC22A12CYP2C9KMT2A | |
| Hydrochloric Acid SCHEMBL11637777 | 0.80 | CYP2C19 (0.50) | CYP2C19EYA3SLC22A12CYP2C9KMT2A | |
| SCHEMBL11637773 | 0.79 | CYP2C19 (0.49) | CYP2C19EYA3SLC22A12CYP2C9KMT2A | |
| SCHEMBL11635688 | 0.79 | CYP2C19 (0.49) | CYP2C19EYA3SLC22A12CYP2C9KMT2A | |
| SCHEMBL4806386 | 0.78 | CYP2C19 (0.69) | CYP2C19EYA3SLC22A12CYP2C9ALDH1A1 | |
| SCHEMBL11373064 | 0.78 | MAPT (0.43) | EYA3SLC22A12CYP2C9KMT2AMEN1 | |
| SCHEMBL11638728 | 0.77 | CYP2C19 (0.47) | CYP2C19EYA3SLC22A12CYP2C9KMT2A | |
| SCHEMBL11638070 | 0.77 | CYP2C19 (0.47) | CYP2C19EYA3SLC22A12CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765078-B2 | Compounds and methods for inhibiting mitotic progression | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| WO-2008021038-A2 | PYRIDOBENZAZEPINE COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |