SCHEMBL11637488

SCHEMBL11637488

CCc1oc2ccccc2c1C(C)C#N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 7/20 0.48
EYA3 Q99504 3/20 0.40
SLC22A12 Q96S37 2/20 0.40
CYP2C9 P11712 6/20 0.38
KMT2A Q03164 3/20 0.38
MEN1 O00255 2/20 0.38
ABCB11 O95342 2/20 0.38
LMNA P02545 2/20 0.38
TTR P02766 2/20 0.38
PGR P06401 2/20 0.38
ADRA2A P08913 2/20 0.38
TBXA2R P21731 2/20 0.38
OPRM1 P35372 2/20 0.38
SLC6A3 Q01959 2/20 0.38
BIRC5 O15392 1/20 0.38
HTR1A P08908 1/20 0.38
DRD1 P21728 1/20 0.38
PTGS1 P23219 1/20 0.38
SLC6A2 P23975 1/20 0.38
PDE4A P27815 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11638728 0.83 CYP2C19 (0.47) CYP2C19EYA3SLC22A12CYP2C9KMT2A
SCHEMBL14299512 0.82 CYP2C19 (0.54) CYP2C19EYA3SLC22A12CYP2C9KMT2A
Hydrochloric Acid SCHEMBL11637777 0.74 CYP2C19 (0.50) CYP2C19EYA3SLC22A12CYP2C9KMT2A
SCHEMBL11640926 0.74 CYP2C19 (0.50) CYP2C19EYA3SLC22A12CYP2C9KMT2A
SCHEMBL11637773 0.73 CYP2C19 (0.49) CYP2C19EYA3SLC22A12CYP2C9KMT2A
SCHEMBL11635688 0.73 CYP2C19 (0.49) CYP2C19EYA3SLC22A12CYP2C9KMT2A
SCHEMBL4806386 0.72 CYP2C19 (0.69) CYP2C19EYA3SLC22A12CYP2C9ALDH1A1
SCHEMBL11637718 0.71 EYA3 (0.42) CYP2C19EYA3SLC22A12CYP2C9KMT2A
SCHEMBL11638070 0.71 CYP2C19 (0.47) CYP2C19EYA3SLC22A12CYP2C9KMT2A
SCHEMBL665373 0.71 CYP2C19 (0.47) CYP2C19EYA3SLC22A12CYP2C9KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114057605-B Method for producing nitrile by gas phase dehydration 化学与精细化工广东省实验室 2024-02-20 CN disclosed
CN-114057605-A Method for preparing nitrile by gas phase dehydration 化学与精细化工广东省实验室 2022-02-18 CN disclosed
US-4124710-A HYPOTENSIVE AGENTS LABAZ (FR) 1978-11-07 US disclosed