Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5092195 | 0.88 | HSD11B1 (0.78) | HSD11B1GAARAB9AHSD11B2NR1I2 | |
| SCHEMBL5095896 | 0.86 | HSD11B1 (0.74) | HSD11B1HSD11B2NR1I2 | |
| SCHEMBL5105117 | 0.86 | HSD11B1 (0.74) | HSD11B1GAAHSD11B2ALDH1A1HSD17B1 | |
| SCHEMBL5098612 | 0.86 | HSD11B1 (0.74) | HSD11B1GAARAB9AHSD11B2NR1I2 | |
| Fig 1 SCHEMBL5095865 | 0.85 | HSD11B1 (1.00) | HSD11B1NR1I2 | |
| SCHEMBL5104995 | 0.83 | HSD11B1 (0.71) | HSD11B1GAARAB9AHSD11B2NR1I2 | |
| SCHEMBL5095961 | 0.83 | HSD11B1 (0.71) | HSD11B1 | |
| SCHEMBL5098044 | 0.83 | HSD11B1 (0.71) | HSD11B1GAARAB9AMEN1ALDH1A1 | |
| SCHEMBL5092127 | 0.82 | HSD11B1 (0.69) | HSD11B1GAARAB9AHSD11B2NR1I2 | |
| SCHEMBL5098543 | 0.82 | HSD11B1 (0.69) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329683-B2 | 11-β-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |