Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.52 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21886886 | 0.91 | GPR119 (0.58) | GPR119PIK3CD | |
| SCHEMBL21886888 | 0.91 | GPR119 (0.58) | GPR119PIK3CD | |
| SCHEMBL21887079 | 0.91 | GPR119 (0.58) | GPR119PIK3CD | |
| SCHEMBL2776233 | 0.89 | GPR119 (0.66) | GPR119DPP4DPP9DPP8IRAK4 | |
| SCHEMBL29616792 | 0.88 | GPR119 (0.48) | GPR119PIK3CD | |
| SCHEMBL28421951 | 0.88 | GPR119 (0.48) | GPR119PIK3CD | |
| SCHEMBL29616651 | 0.85 | GPR119 (0.46) | GPR119PIK3CD | |
| SCHEMBL28416764 | 0.85 | GPR119 (0.46) | GPR119PIK3CD | |
| SCHEMBL31656659 | 0.82 | GPR119 (0.73) | GPR119PIK3CD | |
| SCHEMBL14861989 | 0.82 | GPR119 (0.51) | GPR119PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054368-B1 | CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-09-16 | — | — | EP | disclosed |
| WO-2008024892-A2 | CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-28 | — | — | WO | disclosed |