Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1430513 | 0.93 | IDH1 (0.41) | EPHX2MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL1429603 | 0.91 | EPHX2 (0.47) | EPHX2TRPV4MEN1KMT2AALDH1A1 | |
| SCHEMBL1429802 | 0.89 | EPHX2 (0.47) | EPHX2TRPV4MEN1KMT2AALDH1A1 | |
| SCHEMBL1430066 | 0.86 | EPHX2 (0.41) | EPHX2ALDH1A1TSHRHCRTR1HCRTR2 | |
| SCHEMBL1429672 | 0.86 | EPHX2 (0.41) | EPHX2ALDH1A1TSHRHCRTR1HCRTR2 | |
| SCHEMBL1430556 | 0.84 | TRPV4 (0.42) | EPHX2TRPV4CNR1KCNH2 | |
| SCHEMBL1430068 | 0.84 | TRPV4 (0.42) | EPHX2TRPV4CNR1KCNH2 | |
| SCHEMBL3712617 | 0.77 | POLB (0.47) | MEN1KMT2AALDH1A1ATML3MBTL1 | |
| SCHEMBL1432159 | 0.75 | IDH1 (0.48) | EPHX2MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL2832484 | 0.74 | EPHX2 (0.48) | EPHX2TRPV4MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313413-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES | Convergence Pharmaceuticals Limited (GB) | 2011-04-27 | — | — | EP | disclosed |
| EP-2300432-A1 | PIPERAZINE DERIVATIVES USED AS CAV2.2 CALCIUM CHANNEL MODULATORS | Convergence Pharmaceuticals Limited (GB) | 2011-03-30 | — | — | EP | disclosed |
| WO-2010007073-A1 | PIPERAZINE DERIVATIVES USED AS CAV2.2 CALCIUM CHANNEL MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010007074-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2010-01-21 | — | — | WO | disclosed |