Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.79 |
| ▸ | TNFRSF1A | P19438 | 3/20 | 0.69 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.65 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.64 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.64 |
| ▸ | TUBB | P07437 | 3/20 | 0.64 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.64 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.64 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.64 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.64 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.64 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.64 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.64 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.64 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.64 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.64 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.64 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.64 |
| ▸ | KRAS | P01116 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10582964 | 0.87 | ABCG2 (0.79) | ABCG2TNFRSF1AABCB1LMNAMAPT | |
| SCHEMBL10582957 | 0.87 | ABCG2 (0.79) | ABCG2TNFRSF1AABCB1LMNAMAPT | |
| SCHEMBL14306007 | 0.86 | ABCB1 (0.76) | ABCG2TNFRSF1AABCB1TUBB1TUBB4A | |
| SCHEMBL15807324 | 0.86 | ABCG2 (0.58) | ABCG2TNFRSF1ATUBB1KRASLMNA | |
| SCHEMBL14318031 | 0.85 | ABCG2 (0.80) | ABCG2LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL15807424 | 0.85 | ABCG2 (0.63) | ABCG2TNFRSF1AABCB1LMNAMAPT | |
| SCHEMBL6659039 | 0.83 | ABCG2 (0.88) | ABCG2TNFRSF1AABCB1TUBB1TUBB4A | |
| SCHEMBL6780730 | 0.83 | ABCG2 (0.88) | ABCG2TNFRSF1AABCB1TUBB1TUBB4A | |
| SCHEMBL615819 | 0.83 | ABCG2 (0.88) | ABCG2TNFRSF1AABCB1TUBB1TUBB4A | |
| SCHEMBL10497922 | 0.83 | ABCG2 (0.88) | ABCG2TNFRSF1AABCB1TUBB1TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10737995-B2 | Nuclear receptor modulators and their use for the treatment and prevention of cancer | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-08-11 | — | — | US | disclosed |
| US-20190047932-A1 | NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) | 2019-02-14 | — | — | US | disclosed |
| EP-3333153-A1 | NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER | The U.S.A. as represented by the Secretary, Department of Health and Human Services (US) | 2018-06-13 | — | — | EP | disclosed |
| US-20140171503-A1 | NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER | HUMAN SERVICES (US) | 2014-06-19 | — | — | US | disclosed |
| WO-2012174436-A1 | NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190047932-A1 | NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER | AR, NCOA1, NR5A1 | ABCG2 742/4885TNFRSF1A 777/4885ABCB1 934/4885 |
| US-10737995-B2 | Nuclear receptor modulators and their use for the treatment and prevention of cancer | AR, NCOA1, NR5A1 | ABCG2 742/4885TNFRSF1A 777/4885ABCB1 934/4885 |
| US-20140171503-A1 | NUCLEAR RECEPTOR MODULATORS AND THEIR USE FOR THE TREATMENT AND PREVENTION OF CANCER | AR, NCOA1, NR5A1 | ABCG2 742/4885TNFRSF1A 777/4885ABCB1 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.