SCHEMBL14306331

SCHEMBL14306331

Cc1ccc(N(S)S)nc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 2/20 0.48
CCR5 P51681 2/20 0.48
CCR8 P51685 2/20 0.48
HDAC6 Q9UBN7 2/20 0.48
NOS3 P29474 1/20 0.44
NOS2 P35228 1/20 0.44
ADRA2A P08913 3/20 0.36
ADRA2B P18089 3/20 0.36
ADRA2C P18825 3/20 0.36
RAB9A P51151 2/20 0.36
PLAU P00749 1/20 0.36
MAPT P10636 1/20 0.36
METAP2 P50579 1/20 0.35
CYP3A4 P08684 1/20 0.34
CYP2A6 P11509 1/20 0.34
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC9 Q9UKV0 1/20 0.33
GBA1 P04062 1/20 0.32
ACHE P22303 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL842552 0.78 CCR1 (0.50) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL14236963 0.76 CCR1 (0.48) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL1193460 0.76 HDAC6 (0.48) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL20824742 0.74 CCR1 (0.46) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL6179196 0.74 RAB9A (0.41) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL179288 0.73 GBA1 (0.62) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL12394220 0.73 HDAC6 (0.44) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL13149488 0.71 HDAC6 (0.43) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL8278724 0.71 CCR1 (0.48) CCR1CCR5CCR8HDAC6NOS3
SCHEMBL16248316 0.70 HDAC6 (0.41) CCR1CCR5CCR8HDAC6NOS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2535343-A2 Organoaminosilane precursors and methods for making and using same AIR PRODUCTS AND CHEMICALS, INC. (US) 2012-12-19 EP disclosed