Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 6/20 | 0.50 |
| ▸ | CCND1 | P24385 | 5/20 | 0.50 |
| ▸ | CCND3 | P30281 | 5/20 | 0.50 |
| ▸ | CCND2 | P30279 | 4/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 6/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL188921 | 0.88 | MAPK1 (0.58) | MAPTMAPK1TP53EGFRFGFR1 | |
| SCHEMBL189169 | 0.80 | KDM4E (0.58) | MAPK1FGFR1PDGFRBSRCCDK4 | |
| SCHEMBL4227763 | 0.79 | CDK4 (0.51) | FGFR1CDK4CCND1CCND3CCND2 | |
| SCHEMBL190014 | 0.78 | KDM4E (0.58) | MAPTMAPK1FGFR1PDGFRBPDGFRA | |
| SCHEMBL4355205 | 0.78 | KDM4E (0.50) | MAPK1FGFR1PDGFRBPDGFRACDK4 | |
| SCHEMBL14306582 | 0.77 | CDK4 (0.61) | FGFR1PDGFRBPDGFRACDK4CCND1 | |
| SCHEMBL189897 | 0.77 | KDM4E (0.57) | MAPK1FGFR1CDK4CCND1CCND3 | |
| SCHEMBL4220812 | 0.77 | PIK3CA (0.56) | FGFR1CDK4CCND1CCND3CCND2 | |
| SCHEMBL188696 | 0.76 | CDK4 (0.47) | MAPK1EGFRFGFR1PDGFRBPDGFRA | |
| SCHEMBL3338980 | 0.76 | CDK4 (0.73) | FGFR1PDGFRBPDGFRACDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |