Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 0.51 |
| ▸ | CCND1 | P24385 | 17/20 | 0.51 |
| ▸ | CDK2 | P24941 | 9/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CCND2 | P30279 | 11/20 | 0.51 |
| ▸ | CCND3 | P30281 | 11/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.49 |
| ▸ | CDK1 | P06493 | 4/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4220812 | 0.96 | PIK3CA (0.56) | CDK4CCND1CDK2CCNE1CDK6 | |
| SCHEMBL3337709 | 0.93 | CDK4 (0.59) | CDK4CCND1CDK2CCNE1CDK6 | |
| SCHEMBL4226220 | 0.85 | PIK3CA (0.49) | CDK4CCND1CDK2CCNE1CDK6 | |
| SCHEMBL190014 | 0.85 | KDM4E (0.58) | CDK4CCND1CDK2CCNE1CDK6 | |
| SCHEMBL12102037 | 0.84 | CDK4 (0.46) | CDK4CCND1CDK2CCNE1CDK6 | |
| SCHEMBL14547181 | 0.84 | CDK4 (0.48) | CDK4CCND1CDK2CCNE1CDK6 | |
| SCHEMBL4355205 | 0.82 | KDM4E (0.50) | CDK4CCND1CDK2CCNE1CDK6 | |
| SCHEMBL188696 | 0.82 | CDK4 (0.47) | CDK4CCND1CDK2CCNE1CDK6 | |
| SCHEMBL4225857 | 0.81 | PIK3CA (0.45) | CDK4CCND1CDK2CCNE1CDK6 | |
| SCHEMBL4222668 | 0.81 | PIK3CA (0.45) | CDK4CCND1CDK2CCNE1CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931670-B1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K | EXELIXIS INC (US) | 2012-09-12 | — | — | EP | claimed |
| US-8247408-B2 | Pyridopyrimidinone inhibitors of PI3Kα for the treatment of cancer | EXELIXIS, INC. (US) | 2012-08-21 | — | — | US | claimed |
| US-20090062274-A1 | Pyridopyrimidinone inhibitors of pi3kalpha | EXELIXIS, INC (US) | 2009-03-05 | — | — | US | claimed |
| EP-1931670-B1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K | EXELIXIS INC (US) | 2012-09-12 | — | — | EP | disclosed |
| US-8247408-B2 | Pyridopyrimidinone inhibitors of PI3Kα for the treatment of cancer | EXELIXIS, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-8247408-B2 | Pyridopyrimidinone inhibitors of PI3Kα for the treatment of cancer | EXELIXIS, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20090062274-A1 | Pyridopyrimidinone inhibitors of pi3kalpha | EXELIXIS, INC (US) | 2009-03-05 | — | — | US | disclosed |
| US-20090062274-A1 | Pyridopyrimidinone inhibitors of pi3kalpha | EXELIXIS, INC (US) | 2009-03-05 | — | — | US | disclosed |
| US-20090062274-A1 | Pyridopyrimidinone inhibitors of pi3kalpha | EXELIXIS, INC (US) | 2009-03-05 | — | — | US | disclosed |
| WO-2007044698-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062274-A1 | Pyridopyrimidinone inhibitors of pi3kalpha | PIK3CA, PIK3CD, PIK3CB | CDK4 265/4885CCND1 805/4885CDK2 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.