Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790721 | 0.60 | NPC1 (0.61) | MEN1KMT2ACYP3A4CYP2D6SMN1; SMN2 | |
| Nitrogen SCHEMBL4600304 | 0.59 | ALDH1A1 (0.43) | MEN1KMT2ANPSR1MAPTGCGR | |
| SCHEMBL8944218 | 0.58 | KMT2A (0.43) | MEN1KMT2ANPSR1MAPTGCGR | |
| SCHEMBL6907235 | 0.57 | NR5A1 (0.62) | SMN1; SMN2 | |
| Butyl Chloride SCHEMBL9704868 | 0.56 | NPC1 (0.56) | MEN1KMT2ACYP3A4CYP2D6SMN1; SMN2 | |
| Dimethylamine SCHEMBL3444887 | 0.56 | DRD4 (0.56) | MEN1KMT2ACYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL5599322 | 0.56 | NR5A1 (0.66) | MAPTALOX15LMNASMN1; SMN2 | |
| SCHEMBL11662072 | 0.56 | NR5A1 (0.66) | MAPTALOX15LMNASMN1; SMN2 | |
| SCHEMBL6122097 | 0.56 | NR5A1 (0.66) | MAPTALOX15LMNASMN1; SMN2 | |
| SCHEMBL14129989 | 0.56 | CYP2D6 (1.00) | CYP3A4CYP2D6CYP2C9CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080021056-A1 | Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase | ELAN PHARMACEUTICALS, INC. | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021056-A1 | Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase | BACE1, BACE2, PSEN1 | PSEN1 3/4885PSEN2 7/4885APH1B 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.