Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | PPARG | P37231 | 1/20 | 0.63 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.63 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15267404 | 0.92 | PTGS2 (0.62) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL15267399 | 0.85 | PTGS2 (0.65) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL2880887 | 0.84 | PTGS2 (0.64) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL2886958 | 0.84 | PTGS2 (0.66) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL5534966 | 0.82 | PTGS2 (0.79) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL2885873 | 0.81 | TTR (0.56) | PTGS2PTGS1ABCB11NR1I3CAMK2A | |
| SCHEMBL2888394 | 0.81 | PTGS2 (0.60) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL13688513 | 0.80 | PTGS2 (0.66) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL14307498 | 0.80 | PTGS2 (0.61) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL14308724 | 0.80 | PTGS2 (0.58) | PTGS2PTGS1ABCB11PPARGNR1I3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541398-B2 | Hydrogen sulfide derivatives of non-steroidal anti-inflammatory drugs | ANTIBE THERAPEUTICS INC. (CA) | 2013-09-24 | — | — | US | disclosed |
| WO-2008009127-A1 | HYDROGEN SULFIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | ANTIBE THERAPEUTICS INC. (CA) | 2008-01-24 | — | — | WO | disclosed |