Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.46 |
| ▸ | INSR | P06213 | 8/20 | 0.46 |
| ▸ | LYN | P07948 | 7/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.46 |
| ▸ | FLT4 | P35916 | 6/20 | 0.46 |
| ▸ | FLT3 | P36888 | 6/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.46 |
| ▸ | LCK | P06239 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | STK3 | Q13188 | 5/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | SRC | P12931 | 4/20 | 0.46 |
| ▸ | KIT | P10721 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 4/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.46 |
| ▸ | CSF1R | P07333 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313301 | 1.00 | IGF1R (0.46) | IGF1RINSRLYNFGFR1FLT4 | |
| SCHEMBL14531757 | 0.82 | IGF1R (0.50) | IGF1RINSRLYNFGFR1FLT4 | |
| SCHEMBL14312916 | 0.81 | IGF1R (0.49) | IGF1RINSRLYNFGFR1FLT4 | |
| SCHEMBL14312895 | 0.81 | IGF1R (0.49) | IGF1RINSRLYNFGFR1FLT4 | |
| SCHEMBL5080937 | 0.81 | IGF1R (0.49) | IGF1RINSRLYNFGFR1FLT4 | |
| SCHEMBL14312887 | 0.81 | IGF1R (0.49) | IGF1RINSRLYNFGFR1FLT4 | |
| SCHEMBL14313201 | 0.80 | IGF1R (0.49) | IGF1RINSRLYNFGFR1FLT4 | |
| SCHEMBL14312818 | 0.78 | ACVRL1 (0.49) | IGF1RINSRLYNFGFR1FLT4 | |
| SCHEMBL14313261 | 0.77 | ACVRL1 (0.45) | IGF1RINSRLYNFGFR1FLT4 | |
| SCHEMBL14312903 | 0.77 | ACVRL1 (0.46) | IGF1RINSRLYNFGFR1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-B1 | PYRROLO[2,1-F] [1,2,4]-TRIAZIN-4-YLAMINES AS IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer Pharma AG (DE) | 2012-12-26 | — | — | EP | disclosed |