Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 8/20 | 0.45 |
| ▸ | AXL | P30530 | 3/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 8/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14888116 | 0.97 | MERTK (0.44) | MERTKAXLTYRO3ACVRL1TGFBR1 | |
| SCHEMBL5081073 | 0.96 | MERTK (0.44) | MERTKAXLTYRO3ACVRL1TGFBR1 | |
| SCHEMBL14312776 | 0.93 | MERTK (0.45) | MERTKAXLTYRO3ACVRL1RIPK1 | |
| SCHEMBL5140759 | 0.89 | MERTK (0.47) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL14312897 | 0.89 | TYRO3 (0.47) | MERTKAXLTYRO3ACVRL1RIPK1 | |
| SCHEMBL5141187 | 0.88 | TYRO3 (0.47) | MERTKAXLTYRO3ACVRL1RIPK1 | |
| SCHEMBL14313314 | 0.88 | MERTK (0.44) | MERTKAXLTYRO3 | |
| SCHEMBL5141848 | 0.87 | ACVRL1 (0.44) | MERTKAXLTYRO3ACVRL1RIPK1 | |
| SCHEMBL14312964 | 0.87 | MERTK (0.45) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL14312331 | 0.87 | TYRO3 (0.48) | MERTKAXLTYRO3ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431695-B2 | Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-04-30 | — | — | US | disclosed |
| EP-1945222-B1 | PYRROLO[2,1-F] [1,2,4]-TRIAZIN-4-YLAMINES AS IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer Pharma AG (DE) | 2012-12-26 | — | — | EP | disclosed |