SCHEMBL14320109

SCHEMBL14320109

O=C(O)N1CCc2ccc(OCCCN3CCCCC3)cc2C1

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 20/20 0.81
HRH1 P35367 3/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5100461 0.90 HRH3 (1.00) HRH3
SCHEMBL5106581 0.86 HRH3 (1.00) HRH3HRH1
SCHEMBL5093837 0.85 HRH3 (0.91) HRH3
SCHEMBL14287565 0.85 HRH3 (0.76) HRH3HRH1
SCHEMBL5100989 0.85 HRH3 (0.76) HRH3HRH1
SCHEMBL6071591 0.85 HRH3 (1.00) HRH3HRH1
SCHEMBL5106587 0.83 HRH3 (0.77) HRH3HRH1
SCHEMBL14287764 0.83 HRH3 (0.73) HRH3HRH1
SCHEMBL14287589 0.83 HRH3 (0.94) HRH3HRH1
SCHEMBL5100562 0.83 HRH3 (0.79) HRH3HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7314937-B2 Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses ELI LILLY AND COMPANY (US) 2008-01-01 US disclosed