Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.65 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | RXRA | P19793 | 4/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.56 |
| ▸ | RORC | P51449 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 4/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14320764 | 0.91 | KDM1A (0.54) | ABCG2ABCC1MEN1KMT2ASIRT5 | |
| SCHEMBL14320769 | 0.82 | SYK (0.64) | SYKJAK2MAPT | |
| SCHEMBL14321317 | 0.82 | ABCG2 (0.66) | ABCG2ABCC1MEN1KMT2APDE4B | |
| SCHEMBL14320367 | 0.82 | KDM1A (0.66) | MEN1KMT2ASYKJAK2KDM4E | |
| SCHEMBL14320361 | 0.82 | ABCG2 (0.53) | ABCG2ABCC1ABCB1SYK | |
| SCHEMBL14320415 | 0.81 | SYK (0.54) | SYKJAK2 | |
| SCHEMBL13741113 | 0.81 | MEN1 (0.55) | ABCG2MEN1KMT2AABCB1PDE5A | |
| SCHEMBL14320687 | 0.80 | ABCG2 (0.43) | ABCG2ABCC1MEN1KMT2ASIRT5 | |
| SCHEMBL14320502 | 0.80 | FGFR1 (0.48) | ABCG2MEN1KMT2ASYKJAK2 | |
| SCHEMBL14320626 | 0.80 | ABCG2 (0.66) | ABCG2MEN1KMT2AABCB1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802937-B2 | Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors | ORIGENIS GMBH (DE) | 2017-10-31 | — | — | US | claimed |
| EP-2699579-B1 | PYRAZOLO[4,3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2015-10-07 | — | — | EP | claimed |
| CN-103492389-A | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors | ORIGENIS GMBH | 2014-01-01 | — | — | CN | claimed |
| US-20120329780-A1 | Novel kinase inhibitors | ORIGENIS GMBH (DE) | 2012-12-27 | — | — | US | claimed |
| US-9802937-B2 | Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors | ORIGENIS GMBH (DE) | 2017-10-31 | — | — | US | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| EP-2699579-B1 | PYRAZOLO[4,3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2015-10-07 | — | — | EP | disclosed |
| CN-103492389-A | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors | ORIGENIS GMBH | 2014-01-01 | — | — | CN | disclosed |
| US-20120329780-A1 | Novel kinase inhibitors | ORIGENIS GMBH (DE) | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329780-A1 | Novel kinase inhibitors | LRRK2, MYLK2, MYLK | ABCG2 3810/4885ABCC1 4003/4885MEN1 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.