Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173564 | 0.84 | IGF1R (0.48) | SYKMEN1KMT2AKDM4ETP53 | |
| SCHEMBL162007 | 0.79 | BTK (0.58) | JAK2BTK | |
| SCHEMBL1067997 | 0.78 | BRD4 (0.38) | SYKBTKPDGFRA | |
| SCHEMBL4006827 | 0.78 | BTK (0.56) | BTK | |
| SCHEMBL1065221 | 0.76 | ABL1 (0.41) | JAK2SYKNPC1RAB9AMEN1 | |
| SCHEMBL21275356 | 0.76 | BTK (0.37) | ALDH1A1LMNABTKL3MBTL1 | |
| SCHEMBL1542134 | 0.76 | AURKA (0.48) | JAK2SYKNPC1RAB9AMEN1 | |
| SCHEMBL4006823 | 0.75 | BTK (0.57) | BTK | |
| SCHEMBL28437733 | 0.74 | KDM4E (0.47) | NPC1RAB9AMEN1KMT2AFLT3 | |
| SCHEMBL21275223 | 0.74 | LMNA (0.39) | JAK2SYKNPC1RAB9AFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8536166-B2 | Inhibitors of Burton's tyrosine kinase | ROCHE PALO ALTO LLC (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536166-B2 | Inhibitors of Burton's tyrosine kinase | ROCHE PALO ALTO LLC (US) | 2013-09-17 | — | — | US | disclosed |
| EP-2300459-B1 | NOVEL PHENYLPYRAZINONES AS KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-05-29 | — | — | EP | disclosed |
| EP-2300459-A1 | NOVEL PHENYLPYRAZINONES AS KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-03-30 | — | — | EP | disclosed |
| US-20100004231-A1 | INHIBITORS OF BURTON'S TYROSINE KINASE | ROCHE PALO ALTO LLC | 2010-01-07 | — | — | US | disclosed |
| US-20100004231-A1 | INHIBITORS OF BURTON'S TYROSINE KINASE | ROCHE PALO ALTO LLC | 2010-01-07 | — | — | US | disclosed |
| WO-2010000633-A1 | NOVEL PHENYLPYRAZINONES AS KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004231-A1 | INHIBITORS OF BURTON'S TYROSINE KINASE | BTK, LCK, LYN | JAK2 12/4885SYK 4/4885NPC1 4563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.