SCHEMBL14326433

SCHEMBL14326433

O=C1c2ccc(C#Cc3ccccc3)cc2C(=O)N1O

nearest known ligand 0.56

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 16/20 0.56
HNF4A P41235 1/20 0.44
APP P05067 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL83864 0.83 GRM5 (0.60) GRM5APP
SCHEMBL14326160 0.81 GRM5 (0.63) GRM5
SCHEMBL16927161 0.81 GRM5 (0.54) GRM5
SCHEMBL7678431 0.81 ESR1 (0.58) GRM5
SCHEMBL13433471 0.79 GRM5 (0.51) GRM5
SCHEMBL504644 0.79 GRM5 (0.60) GRM5
SCHEMBL22566778 0.79 GRM5 (0.53) GRM5
SCHEMBL16937189 0.79 GRM5 (0.51) GRM5
SCHEMBL2471106 0.79 ESR1 (0.63) GRM5
SCHEMBL25949972 0.79 KMT2A (0.59) GRM5HNF4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE43880-E1 Solvent free low-melt viscosity imide oligomers and thermosetting polymide composites THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 2012-12-25 US disclosed