Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 10/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312573 | 0.94 | ACVRL1 (0.41) | ACVRL1RIPK1KDM4EKMT2ATNK2 | |
| SCHEMBL14312584 | 0.92 | KDM4E (0.44) | ACVRL1RIPK1KDM4E | |
| SCHEMBL14898496 | 0.90 | ACVRL1 (0.48) | ACVRL1RIPK1KMT2ATNK2 | |
| SCHEMBL14313914 | 0.90 | ACVRL1 (0.41) | ACVRL1KDM4ETNK2 | |
| SCHEMBL14312877 | 0.90 | ACVRL1 (0.48) | ACVRL1RIPK1KMT2ATNK2 | |
| SCHEMBL14313307 | 0.89 | ACVRL1 (0.43) | ACVRL1RIPK1TNK2CHRNB2CHRNB4 | |
| SCHEMBL14327140 | 0.88 | MEN1 (0.41) | ACVRL1KMT2ATNK2CHRNB2CHRNB4 | |
| SCHEMBL14313411 | 0.88 | ACVRL1 (0.39) | ACVRL1TNK2FGFR1 | |
| SCHEMBL14312731 | 0.88 | ACVRL1 (0.46) | ACVRL1MERTKTNK2 | |
| SCHEMBL14312922 | 0.87 | ACVRL1 (0.42) | ACVRL1RIPK1MERTKAXLTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945222-B1 | PYRROLO[2,1-F] [1,2,4]-TRIAZIN-4-YLAMINES AS IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES | Bayer Pharma AG (DE) | 2012-12-26 | — | — | EP | disclosed |