SCHEMBL14329239

SCHEMBL14329239

O=Cc1ccc(CN2C(=O)c3ccccc3C2=O)c(C(F)(F)F)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.57
GRM5 P41594 1/20 0.44
CHRM5 P08912 1/20 0.43
KMT2A Q03164 4/20 0.40
MEN1 O00255 2/20 0.40
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA9 Q16790 1/20 0.40
ADRA1D P25100 1/20 0.39
ADRA1A P35348 1/20 0.39
ADRA1B P35368 1/20 0.39
PKM P14618 2/20 0.37
TSHR P16473 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CASP3 P42574 2/20 0.37
ALDH1A1 P00352 1/20 0.36
P2RX7 Q99572 1/20 0.36
POLB P06746 1/20 0.36
HPGD P15428 1/20 0.36
KIF11 P52732 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14329317 0.88 RXFP1 (0.44) RXFP1GRM5CHRM5KMT2AMEN1
SCHEMBL14329242 0.83 RXFP1 (0.63) RXFP1CHRM5CASP3
SCHEMBL31255159 0.82 GRM5 (0.46) GRM5CHRM5KMT2AMEN1CA12
SCHEMBL16241455 0.81 NR1H2 (0.50) RXFP1GRM5CHRM5KMT2AMEN1
SCHEMBL11100770 0.79 CA12 (0.58) GRM5CHRM5KMT2AMEN1CA12
SCHEMBL19823242 0.79 RXFP1 (0.65) RXFP1KMT2APKMTSHRSMN1; SMN2
SCHEMBL14329302 0.79 RXFP1 (0.61) RXFP1GRM5KMT2AMEN1CA12
SCHEMBL14321712 0.79 RXFP1 (0.61) RXFP1GRM5KMT2AMEN1PKM
SCHEMBL17476611 0.77 GRM5 (0.42) RXFP1GRM5CHRM5KMT2AMEN1
SCHEMBL14329321 0.77 GRM5 (0.42) RXFP1GRM5CHRM5KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3491922-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO Dow AgroSciences LLC (US) 2019-06-05 EP disclosed
EP-2934135-B1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-01-31 EP disclosed
EP-2934118-B1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2018-01-31 EP disclosed
US-20170267629-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-09-21 US disclosed
US-20170267629-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-09-21 US disclosed
US-9701620-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-07-11 US disclosed
US-9701620-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-07-11 US disclosed
US-20170158598-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-06-08 US disclosed
US-20170158598-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-06-08 US disclosed
US-20170158597-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-06-08 US disclosed
US-20140171310-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-20140171310-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-20140171309-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-20140171314-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-20140171308-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-20140171312-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-20140171308-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-20140171312-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2014-06-19 US disclosed
US-20120329649-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC 2012-12-27 US disclosed
US-20120329649-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC 2012-12-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170267629-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS RXFP1 1279/4885GRM5 2610/4885CHRM5 1719/4885
US-20170158597-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS RXFP1 1279/4885GRM5 2610/4885CHRM5 1719/4885
US-20170158598-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS RXFP1 1279/4885GRM5 2610/4885CHRM5 1719/4885
US-20140171312-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS RXFP1 1279/4885GRM5 2610/4885CHRM5 1719/4885
US-20140171310-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS RXFP1 1279/4885GRM5 2610/4885CHRM5 1719/4885
US-20120329649-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS RXFP1 1279/4885GRM5 2610/4885CHRM5 1719/4885
US-20140171314-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS RXFP1 1279/4885GRM5 2610/4885CHRM5 1719/4885
US-20140171309-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS RXFP1 1279/4885GRM5 2610/4885CHRM5 1719/4885
US-20140171308-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS RXFP1 1279/4885GRM5 2610/4885CHRM5 1719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.