Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 7/20 | 0.57 |
| ▸ | KLK1 | P06870 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.39 |
| ▸ | MASP2 | O00187 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | FURIN | P09958 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1433580 | 0.94 | KLKB1 (0.65) | KLKB1KLK1CAPN1MASP2 | |
| SCHEMBL1433306 | 0.93 | KLKB1 (0.55) | KLKB1KLK1CTSLCTSSCAPN1 | |
| SCHEMBL1433064 | 0.92 | KLKB1 (0.61) | KLKB1KLK1CTSLCTSSCAPN1 | |
| SCHEMBL1433003 | 0.91 | KLKB1 (0.54) | KLKB1KLK1CTSLCTSSCAPN1 | |
| SCHEMBL1433464 | 0.91 | KLKB1 (0.60) | KLKB1KLK1CTSLCTSSCAPN1 | |
| SCHEMBL1432898 | 0.90 | KLKB1 (0.71) | KLKB1KLK1 | |
| SCHEMBL1432921 | 0.89 | KLKB1 (0.52) | KLKB1KLK1MASP2FURIN | |
| SCHEMBL1432988 | 0.89 | KLKB1 (0.52) | KLKB1KLK1CAPN1MASP2PSMB5 | |
| SCHEMBL1435369 | 0.88 | KLKB1 (0.51) | KLKB1KLK1CTSLCAPN1MASP2 | |
| SCHEMBL1433449 | 0.88 | KLKB1 (0.57) | KLKB1KLK1CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300428-A1 | AMINOPYRIDINE DERIVATIVES | Vantia Limited (GB) | 2011-03-30 | — | — | EP | disclosed |