Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 11/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 11/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4312635 | 0.77 | KDM4E (0.54) | GABRA1GABRA5GABRB2KDM4EKCNK3 | |
| SCHEMBL8208 | 0.76 | KDM4E (0.64) | GABRA1GABRA5GABRB2KDM4EKCNK3 | |
| SCHEMBL2227900 | 0.75 | KDM4E (0.67) | GABRA1GABRA5GABRB2KDM4EKCNK3 | |
| SCHEMBL1433237 | 0.75 | KCNK3 (0.54) | GABRA1GABRA5GABRB2KDM4EKCNK3 | |
| SCHEMBL1431656 | 0.75 | KCNK3 (0.56) | GABRA1GABRA5GABRB2KDM4EKCNK3 | |
| SCHEMBL1430954 | 0.74 | KCNK3 (0.54) | GABRA1GABRA5GABRB2KDM4EKCNK3 | |
| SCHEMBL1432323 | 0.74 | KCNK3 (0.54) | GABRA1GABRA5GABRB2KDM4EKCNK3 | |
| SCHEMBL22364213 | 0.74 | KCNK3 (0.76) | KDM4EKCNK3KCNK9GAASLC2A1 | |
| SCHEMBL1429960 | 0.73 | KDM4E (0.57) | GABRA1GABRA5GABRB2KDM4EKCNK3 | |
| SCHEMBL1430172 | 0.73 | KDM4E (0.58) | GABRA1GABRA5GABRB2KDM4EKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300470-A2 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS GABA-A RECEPTOR MODULATORS | Sepracor Inc. (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009143156-A2 | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS | SEPRACOR INC. (US) | 2009-11-26 | — | — | WO | disclosed |