Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 6/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 6/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20539899 | 0.78 | LPL (0.38) | LPLLIPGP2RX7MAPK1 | |
| SCHEMBL1988136 | 0.78 | LPL (0.38) | LPLLIPGP2RX7MAPK1 | |
| SCHEMBL23031851 | 0.77 | LPL (0.37) | LPLLIPGP2RX7MAPK1 | |
| SCHEMBL5052586 | 0.74 | LPL (0.35) | LPLLIPGP2RX7 | |
| SCHEMBL21052188 | 0.74 | LPL (0.39) | LPLLIPGP2RX7 | |
| SCHEMBL25930160 | 0.74 | SNCA (0.37) | LPLLIPGP2RX7 | |
| SCHEMBL25064189 | 0.74 | LPL (0.35) | LPLLIPGP2RX7 | |
| SCHEMBL13868374 | 0.73 | LPL (0.34) | LPLLIPG | |
| SCHEMBL22442104 | 0.72 | LPL (0.44) | LPLLIPGP2RX7MAPK1 | |
| SCHEMBL25203833 | 0.72 | CA1 (0.33) | LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327497-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-11-16 | — | — | US | disclosed |
| US-20170327497-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-11-16 | — | — | US | disclosed |
| US-20170327497-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-11-16 | — | — | US | disclosed |
| US-9663514-B2 | Substituted 6-aza-isoindolin-1-one derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-05-30 | — | — | US | disclosed |
| US-9663514-B2 | Substituted 6-aza-isoindolin-1-one derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-05-30 | — | — | US | disclosed |
| US-9663514-B2 | Substituted 6-aza-isoindolin-1-one derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-05-30 | — | — | US | disclosed |
| EP-2723739-B1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL (JP) | 2016-08-24 | — | — | EP | disclosed |
| EP-2723739-B1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL (JP) | 2016-08-24 | — | — | EP | disclosed |
| US-20150274723-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-10-01 | — | — | US | disclosed |
| US-20150274723-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-10-01 | — | — | US | disclosed |
| US-20150274723-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-10-01 | — | — | US | disclosed |
| US-9056873-B2 | Substituted 6-aza-isoindolin-1-one derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-06-16 | — | — | US | disclosed |
| US-9056873-B2 | Substituted 6-aza-isoindolin-1-one derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-06-16 | — | — | US | disclosed |
| US-9056873-B2 | Substituted 6-aza-isoindolin-1-one derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-06-16 | — | — | US | disclosed |
| US-20140206680-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-07-24 | — | — | US | disclosed |
| US-20140206680-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-07-24 | — | — | US | disclosed |
| US-20140206680-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-07-24 | — | — | US | disclosed |
| EP-2723739-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | Takeda Pharmaceutical Company Limited (JP) | 2014-04-30 | — | — | EP | disclosed |
| WO-2012177714-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-12-27 | — | — | WO | disclosed |
| WO-2012177714-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274723-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | SYK, MYD88, BTK | LPL 4095/4885LIPG 2591/4885P2RX7 291/4885 |
| US-20140206680-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | SYK, MYD88, BTK | LPL 4095/4885LIPG 2591/4885P2RX7 291/4885 |
| US-20170327497-A1 | SUBSTITUTED 6-AZA-ISOINDOLIN-1-ONE DERIVATIVES | SYK, MYD88, BTK | LPL 4095/4885LIPG 2591/4885P2RX7 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.