LPL — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL133316	0.87	13/20
SCHEMBL90476	0.76	13/20
SCHEMBL120527	0.75	13/20
SCHEMBL228212	0.71	13/20
SCHEMBL104247	0.65	13/20
SCHEMBL171778	0.65	13/20
SCHEMBL171682	0.59	13/20
SCHEMBL239104	0.56	13/20
SCHEMBL311849	0.56	13/20
SCHEMBL28217	0.56	13/20
SCHEMBL121468	0.54	13/20
SCHEMBL370287	0.54	13/20
SCHEMBL241124	0.53	13/20
SCHEMBL321437	0.53	13/20
SCHEMBL47074	0.53	13/20
SCHEMBL59080	0.53	13/20
SCHEMBL101385	0.53	13/20
SCHEMBL203692	0.51	13/20
SCHEMBL189992	0.50	13/20
SCHEMBL252294	0.50	13/20

Clinical trials — most relevant to LPL by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons	PHASE4	COMPLETED
Lovaza Mechanisms of Action	PHASE4	UNKNOWN
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency	PHASE3	COMPLETED
Efficacy and Safety of Human Lipoprotein Lipase (LPL)[S447X] Expressed by an Adeno-Associated Viral Vector in LPL-deficient Subjects	PHASE2/PHASE3	COMPLETED
Orlistat for the Treatment of Type I Hyperlipoproteinemia	PHASE2	COMPLETED
Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.	PHASE1	RECRUITING
Insulin Regulation of Lipolysis and Lipolysis Proteins	EARLY_PHASE1	RECRUITING
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy	nan	NOT_YET_RECRUITING
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.	nan	UNKNOWN
Lipoprotein Lipase Enzyme Activity Assay Validation and Clinical Assessment	nan	COMPLETED
Study to Re-assess and Re-confirm Data Previously Recorded About the Incidence and Severity of Acute Abdominal Pancreatitis Episodes in Lipoprotein Lipase Deficient (LPLD) Subjects Previously Enrolled on AMT Clinical Studies	nan	UNKNOWN
The Fasting Study - Unraveling the Mechanistic Effects of Prolonged Fasting in Humans.	nan	COMPLETED
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL)	nan	COMPLETED
Effects of Exercise on Fructose-induced Postprandial Lipemia	nan	COMPLETED
High Density Lipoprotein Subspecies and Coronary Disease	nan	COMPLETED
Postprandial Fatty Acid Metabolism in Subjects With Lipoprotein Lipase Deficiency	nan	RECRUITING
Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose	nan	COMPLETED
Body Composition and Very-Low-Density-Lipoprotein-Triglycerides (VLDL-TG) Kinetics	nan	COMPLETED
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.	nan	RECRUITING
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
Genetic Epidemiology of Lipoprotein-Lipid Levels	nan	COMPLETED
Effect of Molecular Hydrogen in Patients With NAFLD	nan	COMPLETED
Lysosomal Acid Lipase (LAL) Deficiency Registry	nan	RECRUITING
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans	nan	COMPLETED
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
The Association of SAA With Apolipoprotein B Affects Cardiovascular Risk	nan	COMPLETED
An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype	nan	COMPLETED
Effect of Cryolipolysis on Insulin Resistance	nan	UNKNOWN
Nutrigenetic Intervention on Blood Lipid Markers and Body Composition of Adults With Overweight and Obesity	nan	COMPLETED
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a LPL binder may also engage these)

Protein	Name	Similarity
P49923	—	1.000	P49923 →
P11153	—	1.000	P11153 →
Q06000	—	1.000	Q06000 →
P11151	—	0.999	P11151 →
O46647	—	0.998	O46647 →
P49060	—	0.997	P49060 →
Q29524	—	0.997	Q29524 →
P55031	—	0.997	P55031 →
P07867	—	0.995	P07867 →
P11602	—	0.995	P11602 →
P11152	—	0.994	P11152 →
LIPC	Hepatic triacylglycerol lipase	0.993	landscape →
Q3SZ79	—	0.993	Q3SZ79 →
O46559	—	0.987	O46559 →
Q9WVG5	—	0.987	Q9WVG5 →
Q32PY2	—	0.985	Q32PY2 →
J3RZ81	—	0.985	J3RZ81 →
Q9BDJ4	—	0.985	Q9BDJ4 →
Q6PA23	—	0.984	Q6PA23 →
Q8VI78	—	0.984	Q8VI78 →
Q8WWY8	—	0.983	Q8WWY8 →
Q8VBX1	—	0.983	Q8VBX1 →
Q8CIV3	—	0.983	Q8CIV3 →
P27656	—	0.982	P27656 →
Q5RBQ5	—	0.981	Q5RBQ5 →
Q53H76	—	0.981	Q53H76 →
Q5XGE9	—	0.978	Q5XGE9 →
P97535	—	0.976	P97535 →
Q5E9H0	—	0.974	Q5E9H0 →
Q6DBU8	—	0.974	Q6DBU8 →