Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | DHODH | Q02127 | 6/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9171378 | 0.92 | ALDH1A1 (0.76) | ALDH1A1TSHRDHODHL3MBTL1HPGD | |
| SCHEMBL1565743 | 0.89 | ALDH1A1 (0.76) | ALDH1A1TSHRDHODHL3MBTL1HPGD | |
| SCHEMBL2406505 | 0.89 | ALDH1A1 (0.76) | ALDH1A1TSHRDHODHL3MBTL1HPGD | |
| SCHEMBL606143 | 0.89 | ALDH1A1 (1.00) | ALDH1A1TSHRDHODHL3MBTL1HPGD | |
| SCHEMBL53323 | 0.89 | ALDH1A1 (1.00) | ALDH1A1TSHRDHODHL3MBTL1HPGD | |
| SCHEMBL22756633 | 0.87 | ALDH1A1 (0.72) | ALDH1A1TSHRDHODHL3MBTL1HPGD | |
| SCHEMBL4859453 | 0.86 | ALDH1A1 (0.71) | ALDH1A1TSHRDHODHL3MBTL1HPGD | |
| SCHEMBL10806154 | 0.86 | ALDH1A1 (0.71) | ALDH1A1TSHRDHODHL3MBTL1HPGD | |
| SCHEMBL3330158 | 0.84 | MEN1 (0.71) | ALDH1A1TSHRDHODHL3MBTL1HPGD | |
| SCHEMBL3151520 | 0.84 | ALDH1A1 (0.67) | ALDH1A1TSHRDHODHL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012175654-A1 | TETRALINE SULFONAMIDE DERIVATIVES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX (BE) | 2012-12-27 | — | — | WO | disclosed |
| WO-2012175654-A1 | TETRALINE SULFONAMIDE DERIVATIVES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX (BE) | 2012-12-27 | — | — | WO | disclosed |