Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14339627 | 0.95 | PRMT5 (0.41) | PRMT5USP30ALOX5APFEN1SMARCA2 | |
| SCHEMBL14339652 | 0.89 | PRMT5 (0.41) | PRMT5USP30ALOX5APFEN1SMARCA2 | |
| SCHEMBL14339748 | 0.88 | USP30 (0.42) | PRMT5USP30ALOX5APFEN1SMARCA2 | |
| SCHEMBL14339706 | 0.88 | TRPV3 (0.41) | PRMT5USP30ALOX5APFEN1SMARCA2 | |
| SCHEMBL14339715 | 0.87 | PRMT5 (0.42) | PRMT5USP30ALOX5APFEN1SMARCA2 | |
| SCHEMBL4938233 | 0.87 | SMARCA2 (0.51) | PRMT5USP30ALOX5APFEN1SMARCA2 | |
| SCHEMBL4946466 | 0.87 | PRMT5 (0.47) | PRMT5USP30ALOX5APFEN1SMARCA2 | |
| SCHEMBL14339740 | 0.84 | IKBKB (0.36) | PRMT5USP30TRPV3IKBKBSMN1; SMN2 | |
| SCHEMBL14339743 | 0.83 | USP30 (0.42) | PRMT5USP30ALOX5APFEN1HPGDS | |
| SCHEMBL4943046 | 0.82 | PRMT5 (0.47) | PRMT5USP30ALOX5APFEN1SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326856-B1 | PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-BETA) INHIBITING ACTIVITY | BAYER HEALTHCARE AG (DE) | 2007-12-19 | — | — | EP | disclosed |