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TRPV3

Transient receptor potential cation channel subfamily V member 3 · Q8NET8 · TRPV3 on Sugi Atlas →

20,084 patent compounds predicted against TRPV3, 8,916 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL893694 SCHEMBL893694 0.65 19/20
SCHEMBL894080 SCHEMBL894080 0.58 19/20
SCHEMBL1550037 SCHEMBL1550037 0.51 15/20
SCHEMBL1549367 SCHEMBL1549367 0.47 13/20
SCHEMBL1752195 SCHEMBL1752195 0.57 12/20
SCHEMBL480206 SCHEMBL480206 0.37 12/20
SCHEMBL707619 SCHEMBL707619 0.35 11/20
SCHEMBL805909 SCHEMBL805909 0.54 9/20
SCHEMBL1259604 SCHEMBL1259604 0.45 9/20
SCHEMBL935976 SCHEMBL935976 0.44 9/20
SCHEMBL936497 SCHEMBL936497 0.44 9/20
SCHEMBL936499 SCHEMBL936499 0.44 9/20
SCHEMBL480192 SCHEMBL480192 0.33 9/20
SCHEMBL480477 SCHEMBL480477 0.33 9/20
SCHEMBL805973 SCHEMBL805973 0.54 8/20
SCHEMBL787618 SCHEMBL787618 0.51 8/20
SCHEMBL792575 SCHEMBL792575 0.44 8/20
SCHEMBL805861 SCHEMBL805861 0.44 8/20
SCHEMBL707986 SCHEMBL707986 0.33 8/20
SCHEMBL1107875 SCHEMBL1107875 0.41 7/20

Clinical trials — most relevant to TRPV3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
TRPV Expression in Subjects With Sensitive Skin PHASE4UNKNOWN
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls PHASE4COMPLETED
The Re-Prosper HF Study PHASE2/PHASE3COMPLETED
Botulinum Toxin Injections for Oral Neuropathic Pain PHASE3COMPLETED
Effect of Botulinum Toxin A on Detrusor Overactivity and Renal Function in Chronic Spinal Cord Injured Patients PHASE2COMPLETED
Ethosuximide to Treat IBS PHASE2COMPLETED
Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy PHASE2RECRUITING
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases PHASE1COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC PHASE1COMPLETED
Do Acid Sensing Ion Channels Contribute to Heartburn? PHASE1COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3 EARLY_PHASE1COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8 EARLY_PHASE1COMPLETED
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1 EARLY_PHASE1RECRUITING
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin nanENROLLING_BY_INVITATION
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures nanCOMPLETED
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon. nanCOMPLETED
Dissecting the Heterogeneity of Oral Cancer Pain nanUNKNOWN
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
Neurogenic Mechanisms in Burning Mouth Syndrome nanCOMPLETED
The Natural History of TRPV4 Neuropathy nanRECRUITING
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy nanENROLLING_BY_INVITATION
Nutrition for Migraine Prevention nanCOMPLETED
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain nanRECRUITING
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor nanCOMPLETED
A Study on the Mechanism of Cough Hypersensitivity nanUNKNOWN
An Investigation Into the Mechanism of Inhalation Cough Challenge nanCOMPLETED
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers nanRECRUITING
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients nanACTIVE_NOT_RECRUITING
Expressions of TRPV1 in Airway of Asthmatics nanWITHDRAWN
Classical Trigeminal Neuralgia and Sodium Channel Mutations nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TRPV3 binder may also engage these)

ProteinNameSimilarity
Q8K424 — 1.000 Q8K424 →
Q704Y3 — 0.998 Q704Y3 →
TRPV1 Transient receptor potential cation channel subfamily V member 1 0.997 landscape →
Q6R5A3 — 0.997 Q6R5A3 →
Q6RX08 — 0.996 Q6RX08 →
A0A1D5PXA5 — 0.995 A0A1D5PXA5 →
Q9EPK8 — 0.994 Q9EPK8 →
Q9ERZ8 — 0.994 Q9ERZ8 →
TRPV4 Transient receptor potential cation channel subfamily V member 4 0.992 landscape →
Q697L1 — 0.992 Q697L1 →
Q61056 — 0.991 Q61056 →
Q9QUQ5 — 0.991 Q9QUQ5 →
P19334 — 0.991 P19334 →
O35433 — 0.991 O35433 →
Q9R186 — 0.990 Q9R186 →
P48994 — 0.990 P48994 →
TRPC1 Short transient receptor potential channel 1 0.990 landscape →
Q9XSM3 — 0.989 Q9XSM3 →
P79100 — 0.989 P79100 →
Q9MYV9 — 0.989 Q9MYV9 →
Q18297 — 0.988 Q18297 →
O35119 — 0.988 O35119 →
P34586 — 0.988 P34586 →
P69744 — 0.988 P69744 →
Q9JIP0 — 0.988 Q9JIP0 →
TRPC4 Short transient receptor potential channel 4 0.988 landscape →
Q5ICL9 — 0.987 Q5ICL9 →
Q9QX29 — 0.987 Q9QX29 →
Q8BH53 — 0.987 Q8BH53 →
Q38998 — 0.987 Q38998 →