Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | BCL9 | O00512 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947196 | 0.92 | PRMT5 (0.43) | ALOX5APFEN1PRMT5CHEK2HTR6 | |
| SCHEMBL4940406 | 0.83 | PRMT5 (0.42) | ALOX5APFEN1PRMT5CHEK2HTR6 | |
| SCHEMBL4946420 | 0.83 | PRMT5 (0.42) | ALOX5APFEN1PRMT5CHEK2HTR6 | |
| SCHEMBL4947771 | 0.82 | PRMT5 (0.43) | ALOX5APFEN1PRMT5CHEK2HTR6 | |
| SCHEMBL14339664 | 0.81 | PRMT5 (0.42) | ALOX5APFEN1PRMT5CHEK2HTR6 | |
| SCHEMBL14028580 | 0.81 | PRMT5 (0.41) | ALOX5APFEN1PRMT5CHEK2HTR6 | |
| SCHEMBL4945773 | 0.81 | PRMT5 (0.41) | ALOX5APFEN1PRMT5CHEK2HTR6 | |
| SCHEMBL4946491 | 0.81 | SCN9A (0.47) | ALOX5APFEN1PRMT5CHEK2HTR6 | |
| SCHEMBL4947749 | 0.80 | HPGD (0.41) | ALOX5APFEN1PRMT5CHEK2HTR6 | |
| SCHEMBL14028576 | 0.79 | PRMT5 (0.42) | ALOX5APFEN1PRMT5CHEK2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326856-B1 | PYRIDINE DERIVATIVES WITH IKB-KINASE (IKK-BETA) INHIBITING ACTIVITY | BAYER HEALTHCARE AG (DE) | 2007-12-19 | — | — | EP | disclosed |