Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235166 | 0.76 | HDAC1 (0.65) | HDAC1HDAC6HDAC3HDAC8HDAC2 | |
| SCHEMBL17483891 | 0.67 | HDAC1 (0.71) | HDAC1HDAC6HDAC3HDAC8HDAC2 | |
| SCHEMBL18088414 | 0.62 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC8HDAC2 | |
| SCHEMBL17483888 | 0.60 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC8HDAC2 | |
| SCHEMBL18046216 | 0.59 | HDAC8 (0.55) | HDAC1HDAC6HDAC3HDAC8HDAC2 | |
| SCHEMBL18046214 | 0.59 | HDAC8 (0.55) | HDAC1HDAC6HDAC3HDAC8HDAC2 | |
| SCHEMBL12049804 | 0.57 | NR1D1 (0.48) | HDAC1HDAC6 | |
| SCHEMBL18046483 | 0.57 | HDAC1 (0.53) | HDAC1HDAC6HDAC3HDAC8HDAC2 | |
| SCHEMBL18046481 | 0.57 | HDAC1 (0.53) | HDAC1HDAC6HDAC3HDAC8HDAC2 | |
| SCHEMBL20989325 | 0.56 | SMN1; SMN2 (0.35) | HDAC1HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1870399-A1 | HYDROXAMATE DERIVATIVES USEFUL AS DEACETYLASE INHIBITORS | Novartis AG (CH) | 2007-12-26 | — | — | EP | disclosed |