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NR1D1

Nuclear receptor subfamily 1 group D member 1 · P20393 · NR1D1 on Sugi Atlas →

8,243 patent compounds predicted against NR1D1, 2,766 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Gsk-4112 Gsk-4112 (SCHEMBL1229706) 1.00 20/20
SCHEMBL1230075 SCHEMBL1230075 0.76 20/20
SCHEMBL1230159 SCHEMBL1230159 0.76 20/20
SCHEMBL8282411 SCHEMBL8282411 0.53 15/20
SCHEMBL3503181 SCHEMBL3503181 0.44 12/20
SCHEMBL3501467 SCHEMBL3501467 0.42 11/20
SCHEMBL3501469 SCHEMBL3501469 0.42 11/20
SCHEMBL3502076 SCHEMBL3502076 0.42 11/20
SCHEMBL8541177 SCHEMBL8541177 0.48 10/20
SCHEMBL3499532 SCHEMBL3499532 0.47 10/20
SCHEMBL3501126 SCHEMBL3501126 0.47 10/20
SCHEMBL8545341 SCHEMBL8545341 0.45 10/20
SCHEMBL3503159 SCHEMBL3503159 0.42 10/20
SCHEMBL654731 SCHEMBL654731 0.68 9/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL7688521) 0.42 9/20
SCHEMBL7671902 SCHEMBL7671902 0.42 8/20
SCHEMBL1585745 SCHEMBL1585745 0.35 8/20
SCHEMBL7048967 SCHEMBL7048967 0.48 7/20
SCHEMBL7753003 SCHEMBL7753003 0.48 7/20
SCHEMBL1937601 SCHEMBL1937601 0.42 7/20

Clinical trials — most relevant to NR1D1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effect of Silymarin in Rheumatoid Arthritis Patients Treated With Methotrexate PHASE4NOT_YET_RECRUITING
Exogenous Melatonin in Intensive Care Unit Chronodisruption PHASE3UNKNOWN
Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes PHASE3COMPLETED
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room PHASE2/PHASE3COMPLETED
The Effect of Calcium and Vitamin D Supplements on Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Patients PHASE3COMPLETED
Activity of Regorafenib in Combination With Chemotherapy in Patients With Advanced Biliary Tract Cancer PHASE1/PHASE2COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Fibrates in Pediatric Cholestasis PHASE2COMPLETED
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis PHASE2ACTIVE_NOT_RECRUITING
Treatment of Chronic Itch in Atopic Dermatitis With Topical Naltrexone PHASE2WITHDRAWN
Choline Effects - Pre-symptomatic AD PHASE1COMPLETED
Metabolic Investigation, Physical Performance, Physical Training At Different Times of the Day in Obese Women nanACTIVE_NOT_RECRUITING
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption nanNOT_YET_RECRUITING
Immunolocalization of 1,25,Dihydroxyvitamin D3 in Aggressive Periodontitis Patients nanCOMPLETED
The Role of Programmed Death Ligand -1 (Pdl-1) in Lung Cancer nanCOMPLETED
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages nanCOMPLETED
Replacement of Vitamin D in Patients With Active Tuberculosis nanCOMPLETED
Assessing the Effects of Alfacalcidol Intake on Expression of Involed Gene in Metabolism in Obese Subjects nanUNKNOWN
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders nanUNKNOWN
RORC Genetic Polymorphism of Rheumatoid Arthritis nanCOMPLETED
The Impact of Selective Vitamin D Receptor Activation on Clinical Outcomes in Septic Patients nanNOT_YET_RECRUITING
Prognostic Value of Vitamin D Levels in Egyptian Females With Breast Cancer nanUNKNOWN
Circadian Clock Gene Expression in Periodontal Disease nanCOMPLETED
Assessment Vitamin D Analogues Intake Pathways on the Proteins Which Involved in Metabolic Rate in Obese Subjects nanUNKNOWN
Vitamin D Levels in Liver Transplantation Recipients Prospective Observational Study nanCOMPLETED
Role of Obeticholic Acid in the Patients of NAFLD With Raised ALT nanCOMPLETED
The Effects of TZD on Fat Metabolism and Insulin Sensitivity in GH-Replaced GHD Patients nanCOMPLETED
Steroid Treatment of Idiopathic Nephrotic Syndrome nanCOMPLETED
PER3 Clock Gene Polymorphism, Clock Gene Expression and Delirium in the Intensive Care Unit. nanWITHDRAWN
Can Dietary Phytoestrogens Slow Down Prostate Tumor Proliferation? nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a NR1D1 binder may also engage these)

ProteinNameSimilarity
Q3UV55 — 1.000 Q3UV55 →
Q08E02 — 1.000 Q08E02 →
Q63503 — 1.000 Q63503 →
B3SV56 — 1.000 B3SV56 →
Q63504 — 0.999 Q63504 →
P16058 — 0.998 P16058 →
P51128 — 0.998 P51128 →
NR4A3 Nuclear receptor subfamily 4 group A member 3 0.997 landscape →
P06211 — 0.997 P06211 →
Q64249 — 0.996 Q64249 →
P50241 — 0.996 P50241 →
P57717 — 0.996 P57717 →
Q07917 — 0.996 Q07917 →
Q9YH33 — 0.995 Q9YH33 →
P49883 — 0.995 P49883 →
P28700 — 0.995 P28700 →
Q05192 — 0.995 Q05192 →
P06212 — 0.995 P06212 →
RORA Nuclear receptor ROR-alpha 0.995 landscape →
Q5R5Y4 — 0.995 Q5R5Y4 →
O18473 — 0.995 O18473 →
P51129 — 0.994 P51129 →
Q9QZB6 — 0.994 Q9QZB6 →
P81559 — 0.994 P81559 →
O18531 — 0.994 O18531 →
RXRB Retinoic acid receptor RXR-beta 0.994 landscape →
P19785 — 0.994 P19785 →
Q9XSB5 — 0.994 Q9XSB5 →
P24610 — 0.994 P24610 →
P12813 — 0.994 P12813 →