Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 15/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 14/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 14/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 14/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 14/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 13/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 13/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8242116 | 0.83 | HDAC1 (0.84) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL8241707 | 0.79 | HDAC1 (0.86) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL8278533 | 0.75 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL13949796 | 0.75 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL8243307 | 0.73 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL8236096 | 0.72 | HDAC1 (0.74) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL18085938 | 0.72 | HDAC1 (1.00) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL8242464 | 0.71 | HDAC1 (0.75) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL8255178 | 0.70 | HDAC1 (0.53) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL8256750 | 0.70 | HDAC1 (0.57) | HDAC1HDAC3HDAC6HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1870399-A1 | HYDROXAMATE DERIVATIVES USEFUL AS DEACETYLASE INHIBITORS | Novartis AG (CH) | 2007-12-26 | — | — | EP | disclosed |